3011 Coelenterazine-SOL in vivo說明

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Nanolight品牌3011 Coelenterazine-SOL in vivo中英文說明書

3011 Coelenterazine-SOL in vivo說明

Cat # 3031 Coelenterazine-SOL in vivo

Native Coelenterazine formulated to be water-soluble and safe for in vivo imaging applications with Gaussia Luciferase.

Coelenterazine is often dissolved in Propyleneglycol (PG) in combination with other alcohols for in vivo imaging studies. Large intravenous doses of PG given over a short period of time can be toxic, including  hyperosmolality, increased anion gap metabolic acidosis (due to lactic acidosis), acute kidney injury, and sepsis-like syndrome.

This can be avoided using water-soluble Coelenterazine. It is formulated to be isosmotic and easily secreted by the kidneys. Thus save for repeated i.v. injections. Water-soluble Coelenterazine can be injected up to a 500 µg/100 µl concentration, achieving very high Coelenterazine levels within the body and leADIng to high Gaussia luciferase signals.